Alzheimer’s disease is one of the disorders that is related to the memory deficits and is an accumulation in the brain of a protein that is named as b-amyloid. The proteins in the brain are known as plaques that further compile the unique proteins on the surface of the brain cells that are known as receptors. This condition further spreads and leads to cell death.
A team of researchers from the UCLA have recently made a discovery of a new drug, which blocks the b-amyloid plaques from combining with the brain cells, thus preventing the cell death. This research study has been recently published in the journal Nature Chemistry.
The assistant professor of neurology, Dr. Lin Jiang along with a professor of biochemistry and chemistry and of the biological chemistry at the UCLA, David Eisenberg have recently identified the plague that is biding the site of b-amyloid with its receptors by determining the 3D structure. The understanding of this interaction is considered as an important step towards the discovery of the drug in order to prevent the interaction among the brain cells and toxic proteins. The team of researchers have made use of computer software in order to help in the procedure of drug selection.
Dr, Lin Jiang further stated that they were searching for a molecule, which will block the receptor just like a shield and help in further preventing the b-amyloid from combining and killing the brain cells. After a detailed search of more than 32,000 molecules, one drug named – ALI6 has offered positive results in the cell-based experiments.