Chronic diseases such as arthritis have been a glaring issue for a majority of population across the world, especially among the geriatrics but now, stem cells modified for autonomous regenerative therapy (SMART) cells promises to pave a way for effective treatment. It has been detected that stem cell technology can be used to treat inflammation by detecting the exact location of the pain, although only when necessary, according to Farshid Guilak, a professor of Orthopedic Surgery at Washington University School of Medicine, who is a senior author the new study.
Stem Cell Technology Can Speed-up Vaccine Effectiveness
It has been observed that genetic engineering is useful in rewiring cell circuits in a way to change the connection between inflammatory mediators and their respective antagonists. Stem cell technology aids by providing a platform for cell-based drug to be delivered at desired location which in turn escalates the rate of vaccine functioning.
This is a major step forward in the right direction as far as arthritis treatment is concerned as current drug therapies often interfere with inflammatory response of the entire body, which leads to several other severe complications. According to Guilak, if everything goes according to plan, engineered cells from stem cell technology would only block inflammation when desired signals are released.
Specific Mouse Cells Were Grown and Studied
This study used body’s inflammation response, called as TNF-alpha inhibitor, via CRISPR technology, to subject a drug that overlaps the inflammation mediator. Using synthetic biology tools, the study detected that recoding the program that is used by stem cell to orchestrate inflammation was possible, and this hijacking is expected to create cells that produce efficient drug for arthritis treatment. The researchers believe that this strategy involving stem cell technology may work for other chronic diseases too, including diabetes, wherein they hope to make stem cells that will sense glucose and activate insulin as a response.