Research Discovers a Hormone that Rises in Bloodstream in Cold and Exercise

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Sad but unfortunately its true, we don’t all respond equally to all types of exercise. Researchers at Joslin Diabetes Center have found out a new kind of clue to this variable response, they have discovered a hormone whose levels in the bloodstream rise sharply in exercise as well as in cold.

Molecule Released from Brown Fat Offers Beneficial Metabolic Effects

The finding came from the very first comprehensive study of fat-controlling hormones also known as lipokines in exercise. Laurie Goodyear, Ph.D., Head of Joslin’s Section on Integrative Physiology and Metabolism and senior author on a report said that this is a whole new subject in research on exercise metabolism, and it seems that they have found another mechanism through which exercise can have beneficial effects.

Experiments in both mice and humans have exhibited that levels of one lipokine, with the cumbersome name of 12,13-diHOME and it climbs substantially in exercise, unlike the levels of other lipokines that have been analyzed.

The study followed up on the said research that has been published last year in joint work with the lab of Joslin’s Yu-Hua Tseng, Ph.D. This collaboration did an exploration of the release of lipokines from brown fat, which can burn energy in various mammals or people who have been exposed to cold. In both humans and mice, the researchers have exhibited that the 12, 13-diHome molecule was released from brown fat during exposure to cold and made an offering of beneficial metabolic effects.

The said research was published on Cell Metabolism, a journal.

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