Presence of Glucose in Lung Environment May Influence Immune system

A new study suggests that presence of glucose or simple sugar in lung environment might have an effect on the immune system. Scientists have confirmed this on mouse models. The University of Manchester in the U.K. conducted the study to develop improved therapies for respiratory ailments. Nature Immunology journal published the study.

The lead researcher, Andrew MacDonald states, both, developed and developing nations have many people suffering from respiratory conditions. He also says that concept of changing glucose level in the lungs can help in treatment of such diseases in future. This scope is an exciting opportunity for scientists in developing new therapies.

Scientists have figured an interesting connection between the behavior of microphages and availability of sugar in lung environment. Microphages are special immune cells that stimulate inflammation.

Various Respiratory Issues Encourage Scientists to Lookout for Innovative Therapy Methods

Several individual in the United States and all over the world suffer from chronic respiratory illnesses. According to statistics from the Office of Disease Prevention and Health Promotion, around 25 mn individuals in the U.S. suffer from asthma. It is a serious respiratory ailment causing shortness of breath.

As a result, the study holds an important significance as millions suffer from respiratory issues. Further, scientists are consistently looking out for innovations that provide better therapies.

The research says, blocking glucose in lungs can help decrease inflammation in case of chronic respiratory illness. However, increasing glucose level can help immune response in individuals with respiratory issues.

Various investors, research bodies, pharmaceutical firms, and non-profit organizations funded the study. For example, the Medical Research Council and Biotechnology and Biological Sciences Research Council in the U.K., the Wellcome Trust in London, Asthma UK, the National Institutes of Health (NIH) in the U.S., and AstraZeneca funded the research.

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