While we are aware that the risk of kidney disease increases with diabetes, a new study from Washington University School of Medicine has suggested that the converse is also possible. Kidney dysfunction can enhance the chances of diabetes. Researchers have also stated that it is urea which is connecting the kidney disease with diabetes and vice versa. Urea can build up in the kidneys when the kidney function slows down. When there is a buildup of urea in the blood on account of kidney dysfunction there is an increased resistance to insulin resulting in impaired insulin secretion. The good news is that urea levels in the kidneys can be lowered through medicines and also by taking less amount of protein in the daily diet. This in turn is expected to improve the treatment of diabetes as well as for the prevention of diabetes.
The author of the study, Ziyad Al-Aly Washington University, said that he was greatly inspired about the relationship between diabetes and kidney disease after he read a study which was published in 2016 journal of clinical investigation which was based on mouse. As per the study, the researchers from the University of Montreal Hospital Research Center in Canada had induced kidney failure among mice, on account of which many of the mice had high urea levels. The high urea levels in the blood then caused increased insulin resistance. It also impaired insulin secretion. So, after reading this research, Ziyad Al-Aly was curious and he wondered if this is the result in mice, then similar results may persist in humans. This lead to a similar test among humans and the result of the test on humans proved to be exactly the same as the result in the study conducted on mice. The conclusion of this result was that there is a very evident relationship between high urea levels and risk of diabetes.