An upcoming research suggests that a typical Western diet with high dietary fat content, along with alterations in fat-based metabolism could increase the chances of cancer cells to grow. The research carried out at Cancer Center located at the Beth Israel Deaconess Medical Center, focused its study on how genetic processes could lead towards cancer metastasis in mice. Based on the information, the researchers linked high fat diet as a major factor that could induce cancer metastasis.
More Insights on High Diet Fat Based Cancer Progression
According to the study, fatalities resulting from metastatic cancers like the prostate cancer are quite high in the United States, where a high-fat diet is predominant. These rates are compared to the cancer metastasis instances recorded from other countries, where fat intake in diets is usually found to be low. The study reveals that the ratio of prostate cancer scenarios that reach metastatic stage in U.S. and other countries, especially the Asian ones is 40:10. This indicates the role of prominent environmental factors that may induce changes in the genetics to cause a progressive action. According to Pier Paolo Pandolfi, a senior author of this study, the research data shows a strong genetic link for cancers, especially the prostate ones to get a boost after diets are altered to include more fat.
It has been found out that the PTEN tumor suppressor gene plays a crucial influencing factor in prostate cancer occurrences. According to the research, a loss of this gene takes place in at least 70% of prostate tumor progressions, resulting in metastasis. But, the researchers found out that another tumor suppressor gene called was responsible for triggering the progressive state, but was also absent in at least one-third of the cases. Apart from this, it was recorded that at least 20% of the tumor occurrences did not show presence of both PTEN as well as PML. The research compared both kinds of tumor, i.e. the ones that did not have only the PTEN gene and the tumors which depicted absence of both the suppressor genes. This comparison brought to light the production of large amount of fats and lipids during the metastatic tumor growth. Also, in cases where both genes were absent, the fat production processes of the cells were behaving in an unrestrained manner.