FKBP51-protein Inhibitors Could Help Reduce Diabetes and Obesity

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Researchers have known for some time that the protein FKBP51 has a notable association with conditions such as anxiety disorder and depression. The protein is associated with the regulation of the body’s stress system. When the stress system is not functioning properly, chances of mental disorders developing are high.

Researchers from the Max Planck Institute of Psychiatry have now discovered a surprising new role pertaining to the protein. Researchers have found out that the protein works as a molecular link between the body’s metabolic processes and stress regulatory system. The protein guides a signal in muscle tissue, which, especially with the intake of excessive calories, acts as a trigger for glucose intolerance.

Glucose intolerance is the leading indicator of type 2 diabetes. Unhealthy diets, with high fat proportions are a stress booster for the body. When FKBP51 is produced in high quantities in the muscle, the absorption of glucose is reduced. As a result, disorders such as obesity and diabetes may develop. If the protein is blocked, diabetes will not be developed, even if the body is under a lot of stress or if it has had too many calories. Less quantity of FKBP51 in the muscle tissue will mean less intolerance to glucose and thus normal metabolism.

The protein can be blocked medically with the help of anti-protein compounds developed at the Max Planck Institute. These compounds will be developed for clinical trials. These findings could help develop new treatment approach for conditions such as diabetes and several other metabolic diseases.

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