Duke university is moving from strength to strength in terms of research. Recently, biomedical engineers from the university paved the way for next generation of medical application. Using disordered proteins, which they stabilized by manipulating external factors, researchers achieved this feat.
Significance and Context of Research Study Decoded
The research is particularly significant because it gives insight into behavior, previously unexamined. And, with the research, novel materials can now be obtained. Consequently, this can give way to improved drug delivery, biotechnology advancement, tissue engineering and regenerative medicine.
It is important to note here that so far, researchers felt proteins needed to fold into 3-D shapes to function. This study proves, it might not be the only case. IDPs or intrinsically disordered pairs can extend help to medical application effectively.
Here, the fact that IDPs are important for they go through phase transitions, becoming valuable to biotechnology, is crucial. Also, it is important to note that environment triggers play a role in these transitions. For instance, temperature can trigger liquid to convert to gel and an insoluble state to soluble state, including vice-versa of the phenomenon. Thus, IDPs emerge as the effective way forward in terms of drug deliveries.
Besides, the fact that these are injectable as liquids, later solidifying inside bodies only helps their popularity in concerned circles. They then transform into gel hubs, releasing medicine gradually. But it is important to make note here that while the flexibility makes IDP desirable, the same structure caused instability.
But, this instability can now be manipulated, thanks to the study. Felipe Garcia Quiroz explains the change succinctly. He states that new tools paved way for more creativity. And, this led to widening of range of applicability of IDP-based material. This is exciting – both for Material Science as well as Biology.
The journal Science Advances is carrying comprehensive details of the study.