Development in Treatment of Crohn’s Disease


A new type of bacterial enzyme, called urease, has been identified to be the main cause of imbalance in the gut microbiome that is connected to Crohn’s disease. The study indicates that if a substantial part of the bacteria is removed from the gut microbiome and then a specific type of good bacteria that do not have this bacterial enzyme is re-introduced then it is possible to provide the patients with an effective treatment for the disease.

Probable Causes for the Disease

 A research by Penn Medicine has singled out this bacterial enzyme. The study that has been published online in the Science Translational Medicine indicates the approach of taking out that specific bacterial enzyme and then re-introducing the “good” bacteria as an effective one. The imbalance of gut microbiome, called dysbiosis, is caused due to various environmental stressors like diet, antibiotics, and inflammation of the intestines. This condition of dysbiosis is believed to trigger the Crohn’s disease and some other diseases as well. However, the mechanism that leads to such a relationship has not been completely understood as of yet. The disease is believed to affect a million adults and children alike in the United States.

Labelling the study as “important”, Gary D. Wu, Associate Chief of research at Perelman School of Medicine, University of Pennsylvania, said that movement of nitrogen into bacteria is revealed through this study and it is an important process in the development of dysbiosis.

The research has been funded by the Crohn’s and Colitis Foundation.

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