Development of New Artificial Human Prion to Generate Hopes for Effective Therapeutics

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A team of researchers from the Case Western Reserve University Medicine School have designed and synthesized the first artificial human prior. This has been considered as a dramatic development that has been taken efforts to combat a devastating form of a brain disease that has been till now eluded a cure and treatment. The research study and the new findings have been published in Nature Communications.

Prions are basically proteins that have been folded in an incorrect manner. They can merge with the adjacent normal proteins in the human brain, which are further expected to trigger a domino effect that will result in microscopic holes and further convert the brain into a sponge. This change results in dementia, progressive deterioration, and certain death. There are several types of prion diseases that are being faced by humans, and Creutzfeldt-Jakob disease is considered one of the most common. How and why the human prion mis-folds has always remained a big mystery, for which a team of researchers have been asked to solve the issue and work on new findings.

The team of researchers have stated that their understanding of prions in the human brain has been limited till now. However, now being able to generate synthetic human prions in a test tube as they have now done will allow them to achieve a comparatively richer understanding of prion replication and structure. This is basically as very important step for the emerging inhibitors and their replication in the human brain, which is quite necessary for stopping the prion-based brain disease. The new findings have raised hopes for several new therapeutics and treatment strategies making use of analog medications with blocking or inhibiting effect on the human prion replication.

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