Cancer Treatment to Benefit from Drugs that Block NFS1

A recently published study states that the producing more of a protein lung adenocarcinoma cells survive oxygen threat. The name of this protein which is produced is NFS1. The author of the study Richard Possemato who is an assistant professor at the school of medicine at NYU, in the department of Pathology, said that their data supports the theory that NFS1 offers central protection for cancer cells against oxygen which is what their team of researchers plan to take away.

Research team made use of helping others to switch off over 2500 genes which was related to cell metabolism one by one. The result of this experiment was that many genes which are important to survive in escalated oxygen levels are not as essential for survival in low oxygen. Research also found that NFS1 turned out to be the most vital gene for survival at high oxygen levels in the lungs but not so much in lower oxygen levels by cells under the skin. It was found that cancer cells when injected under the skin of mice in a low oxygen environment irrespective of the presence of NFS1 the cells grew well in both the cases. However, on account of the presence of elevated oxygen levels in the lungs the same cells failed to form tumors in the lungs. Researchers therefore, decided to apply the same findings in mice on human data sets and found at NFS1 levels were high in lung adenocarcinoma cells as compared to other tissues.

NFS1 might be critical to lung cancer cell survival in more than one way. If NFS1 is not active enough cancer cells can run out of key building blocks for proteins and stop multiplying. The study suggests that in future anti cancer treatments can include drugs that block NFS1, which in turn will encourage the death of cancer cells.

 

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