The body uses a mechanism of preventing the building of such toxic materials, which is known as autophagy or self-eating. However, among the neurodegenerative diseases, this mechanism fails. Further, the population explosion is leading to an increasing number of patients suffering from neurodegenerative diseases. However, there are no effective drugs present to induce autophagy. Thus, scientists are looking to explore new drugs. Additionally, they are researching into ways for existing drugs to treat these diseases.
A new study finds that medicines used in the treatment of blood pressure impacts the treatment of numerous other conditions. The drug is effective against deadly conditions such as Huntington’s, Parkinson’s, and other types of dementia. Huntington’s and Parkinson’s diseases are collectively referred to as neurodegenerative diseases. Additionally, these diseases have a common feature of building misfolded proteins. These proteins aggregate and cause irreversible damage to nerve cells present in the brain. The researchers at the University of Cambridge conducted the study and the journal Nature Communications published the study.
Lab Experiments Demonstrate Lower Disease Incidence
Dementia Research Institute and the Cambridge Institute for Medical Research are lending a hand in the experiments. These researchers report that drugs such as felodipine has potential to treat hypertension.
Felodipine effectively reduced the building and aggregating in the experiment during the study, conducted on lab mice. After these tests, the animals showed fewer signs of disease incidence.
However, these studies are at a preliminary stage. In the next stage, the researchers are planning to conduct tests on humans to verify its effectiveness. This stage is a bit difficult as the researchers need to be more cautious.
Moreover, this is the first time that the study exhibited and approved drugs for lowering the buildup of harmful proteins. The proteins in the mice’s brain aim to mimic the drug seen in humans.