Analytical testing has been a key advancement for all-phase drug development and pharmaceutical manufacturing. Industry experts such as Shimadzu pharmaceuticals marketing manager, Gurmil Gendeh, Malvern life science sector marketing manager, Lisa Newey-Keane, and Bruker biopharma market area manager, Guillaume Tremintin have shared their views on the role of analytical testing development in addressing challenges of pharmaceutical analysis.
Analytical Instrumentation Development Birthed 3 Trends in 10 Years
When asked about the evolution of analytical tools over the past decade for testing biologics and small molecules, Newey-Keane has mentioned three important trends being addressed. The first has been a telling upswing in the development of small-molecule generic drugs. Secondly, a move toward continuous manufacture (CM) in the pharma sector and finally, rising awareness of the power and significance of orthogonality in biologics have already been showcased.
What about drug development and its success rate? Tremintin has explained that the most noteworthy of all advances in analytical testing could be attributed to high-resolution measurements that allow users to speed up their protein characterization tasks.
Uninformed Vendors Encounter Challenges to Achieve, Interpret Results
Customers using new analytical tools could find it perplexing to obtain results or interpret them without sufficient understanding of the concept of measurements. Wyatt Technology Corporation president, Geofrey Wyatt has said it is a very realistic and frightening possibility. Researchers could have little understanding of whether something’s wrong with the sample preparation or measurement itself that they receive random numbers, or whether the numbers really mean something. Proper training and usage of right tools, however, could solve the problem. For instance, the Wyatt Technology offers a course that helps attendees decipher light scattering through a teaching on data interpretation, sample preparation, practice, and theory.
Amid challenges in analytical testing, there could be enough room for advancement in innovative chemistries as well as automation, according to Gendeh. For instance, Shimadzu’s Perfinity platform could fully automate tryptic digestion. Its nSMOL Antibody Bioanalysis Kit is an antibody bioanalysis solution for sample preparation based on the nanotechnology.